Losing Andrew Luck hasn't slowed down the Indianapolis Colts.

The team now led by quarterback Jacoby Brissett is atop the AFC South division with a 4-2 record heading into Sunday's 11 a.m. match-up with the 2-5 Denver Broncos. The Colts season includes an impressive win over the Kansas City Chiefs.

Brissett has thrown for 14 touchdowns and just three interceptions as Luck's heir. Running back Marlon Mack leads Indianapolis' 10th-ranked rushing attack.

Denver is coming off a long break and a disappointing Thursday night home loss to the Chiefs. The Broncos passing offense will look different Sunday after Emmanuel Sanders was traded away this week.

Here's how Denver matches up with Indianapolis:

When the Broncos run the ball: Denver offense averaging 109.6 rushing yards per game (16th best in the NFL) vs. Indianapolis defense averaging 111.0 rushing yards per game (19th best in the NFL)

When the Broncos pass: Denver offense averaging 207.9 passing yards per game (26th best in the NFL) vs. Indianapolis defense averaging 250.2 passing yards per game (20th in the NFL).

When the Colts run the ball: Indianapolis offense averaging 128.7 rushing yards per game (10th best in the NFL) vs. Denver defense averaging 107.3 rushing yards per game (16th best in the NFL).

When the Colts pass: Indianapolis offense averaging 221.8 passing yards per game (24th in the NFL) vs. Denver defense averaging 195.3 passing yards per game (3rd best in the NFL).